Protein Aggregation and Pore-Formation of a Neurodegenerative Protein Fragment
نویسندگان
چکیده
منابع مشابه
Neurodegenerative aspects of protein aggregation.
Protein aggregation and amyloid fibril deposits are characteristic features of more than twenty pathologic conditions characterized by plaque deposition in the central nervous system. Recent studies point out relationships between protein misfolding and numerous serious diseases. Despite different origins (sporadic, familial or transmissible), they are sometimes called conformational diseases t...
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Protein aggregation and degradation mechanisms in neurodegenerative diseases.
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P rotein aggregation is thought to be the pathological driving force responsible for neurodegenerative disorders such as Alzheimer’s, Parkinson’s, Huntington’s and prion diseases. However, it is not yet clear whether, or to what extent, the misfolded proteins are the cause of the disease rather than the consequence. The aggregated proteins that are characteristic of these diseases have in commo...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.2158